Jeanine L. Page, Mary C. Johnson, Katy M. Olsavsky, Steven C. Strom, Helmut Zarbl, and Curtis J. Omiecinski, Gene Expression Profiling of Extracellular Matrix as an Effector of Human Hepatocyte Phenotype in Primary Cell Culture. TOXICOLOGICAL SCIENCES 97(2), 384–397 (2007).
Katy M. Olsavsky, Jeanine L. Page, Mary C. Johnson, Helmut Zarbl, Stephen C. Strom, Curtis J. Omiecinski, Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues. Toxicology and Applied Pharmacology xx (2007) xxx–xxx.
Matthew A. Stoner, Scott S. Auerbach, Stephanie M. Zamule, Stephen C. Strom and Curtis J. Omiecinski, Transactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites. Nucleic Acids Research, 2007, 1–14.
Scott S. Auerbach, Joshua G. DeKeyser, Matthew A. Stoner, and Curtis J. Omiecinski, CAR2 Displays Unique Ligand Binding and RXR Heterodimerization Characteristics. Drug Metabolism and Disposition, 2007, 428-439.
Stephanie R. Faucette, Tong-Cun Zhang, Rick Moore, Tatsuya Sueyoshi, Curtis J. Omiecinski, Edward L. LeCluyse, Masahiko Negishi, and Hongbing Wang, Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers. The Journal of Pharmacology and Experimental Therapeutics, 2007, 320:72–80.
Shun-Hsin Liang, Christopher Hassett, and Curtis J. Omiecinski, Alternative Promoters Determine Tissue-Specific Expression Profiles of the Human Microsomal Epoxide Hydrolase Gene (EPHX1). Molecular Pharmacology, 67:220–230, 2005.
Scott S. Auerbach, Matthew A. Stoner, Shengzhong Su, and Curtis J. Omiecinski, Retinoid X Receptor-α Dependent Transactivation by a Naturally Occurring Structural Variant of Human Constitutive Androstane Receptor (NR1I3). Molecular Pharmacology 68:1239–1253, 2005.
Sherif Z. Abdel-Rahman, Marinel M. Ammenheuser, Curtis J. Omiecinski, Jeffrey K. Wickliffe, Judah I. Rosenblatt, and Jonathan B. Ward, Jr., Variability in Human Sensitivity to 1,3-Butadiene: Influence of Polymorphisms in the 5#-Flanking Region of the Microsomal Epoxide Hydrolase Gene (EPHX1). Toxicological Sciences 85, 624–631 2005.
Hosagrahara VP; Rettie AE, Hassett C, Omiecinski CJ. Functional analysis of human microsomal epoxide hydrolase genetic variants. Chem Biol Interac 150: 149-159, 2004.
Liang SH, Hassett C, Omiecinski CJ. Alternative promoters determine tissue-specific expression profiles of the human microsomal epoxide hydrolase gene (EPHX1). Molecular Pharmacology 67: 1-11, 2005.
Abdel-Rahman SZ, Ammenheuser MM, Omiecinski CJ, Wickliffe JK, Rosenblatt JI, Ward JB Jr . Variability in human sensitivity to 1,3-butadiene: influence of polymorphisms in the 5'-flanking region of the microsomal epoxide hydrolase gene (EPHX1). Toxicological Science 85: 624-631, 2005.
Auerbach SS, Su S, Stoner MA, Omiecinski CJ. RXR-dependent transactivation by a naturally occurring structural variant of human CAR (NR1I3). Molecular Pharmacology 68, 2005, 68: 1239-1253, 2005.
Sidhu JS, Liu F, Omiecinski CJ. Phenobarbital responsiveness as a uniquely sensitive indicator of hepatocyte differentiation status: requirement of dexamethasone and extracellular matrix in establishing the functional integrity of cultured primary rat hepatocytes. Experimental Cell Research 292: 252-264, 2004.
Yamamoto M, Mise M, Matsumoto S, Ito S, Gohyama N, Ishida S, Sagara Y, Omiecinski CJ, Oguri K, Yamada H. Comparison of Genomic and cDNA Sequences of Guinea Pig CYP2B18 and Rat CYP2B2: Absence of a Phenobarbital-responsive Enhancer Module in the Upstream Region of the CYP2B18 Gene. J Biochem Molec Toxicol 18: 124-130, 2004.
Scott S. Auerbach, Richard Ramsden, Matthew A. Stoner, Christophe Verlinde, Christopher Hassett and Curtis J. Omiecinski, Alternatively spliced isoforms of the human constitutive androstane receptor. Nucleic Acids Research, 2003, Vol. 31, No. 12.
Sidhu JS, Liu F, Boyle SM, Omiecinski CJ. PI3K inhibitors reverse the suppressive actions of insulin on CYP2E1 expression by activating stress-response pathways in primary rat hepatocytes, Molecular Pharmacology 59: 1-9, 2001.
Farin FM, Janssen P, Quigley S, Abbott D, Hassett C, Smith-Weller T, Franklin GM, Swanson PD, Longstreth WT, Jr., Omiecinski CJ, Checkoway H. Genetic polymorphisms of microsomal and soluble epoxide hydrolase and the risk of Parkinson's disease, Pharmacogenetics 11: 703-708, 2001.
Krovat BC, Tracy JH, Omiecinski CJ. Fingerprinting of cytochrome P450 and microsomal epoxide hydrolase gene expression in human blood cells. Toxicol Sci 55: 352-360, 2000.
Schilter B, Andersen MR, Acharya C, Omiecinski CJ. Activation of cytochrome P450 gene expression in the rat brain by phenobarbital-like inducers, J Pharm Exptl Therapeut, 294, 916-922, 2000.
Beck NB, Sidhu JS, Omiecinski CJ . Baculovirus vectors repress phenobarbital-mediated gene induction and stimulate cytokine expression in primary cultures of rat hepatocytes, Gene Therapy 7: 1274-1283, 2000.
Sandberg M, Hassett C, Adman ET, Meijer J, Omiecinski CJ. Identification and functional characterization of human soluble epoxide hydrolase genetic polymorphisms, J Biological Chemistry 275: 28873-28881, 2000.
Ramsden R, Beck NA, Sommer KM, and Omiecinski, CJ. Phenobarbital responsiveness conferred by the rat CYP2B2 5'-flanking region in transgenic mice, Gene 228 (1-2): 169-179, 1999.
Raaka S, Hassett C, Omiecinski CJ. Human microsomal epoxide hydrolase: 5'-flanking region genetic polymorphisms. Carcinogenesis 19: 387-393, 1998.
Sidhu JS, Omiecinski CJ. Protein synthesis inhibitors exhibit a non-specific effect on phenobarbital-inducible cytochrome P450 gene expression in primary rat hepatocytes. J Biological Chemistry 273: 4769-4775, 1998.
Hassett C, Sidhu JS, Aicher L, Omiecinski CJ. Human microsomal epoxide hydrolase: genetic polymorphism and functional expression of amino acid variants in vitro. Human Molecular Genetics 3: 421-428, 1994.
Humbert R, Adler DA, Diesteche CM, Hassett C, Omiecinski CJ, Furlong CE. The molecular basis of the human serum paraoxonase activity polymorphism. Nature Genetics 3: 73-76, 1993.