Postdoctoral Work, Department of Microbiology and Immunology, University of California, Los Angeles

Ph.D., Microbiology and Molecular Genetics, University of California, Los Angeles

B.S. with Honors in Molecular and Cell Biology, University Scholars Program, The Pennsylvania State University

Centers

Member of the Center for Infectious Disease Dynamics (CIDD)

Mann, P.B., Barbarich, J., Goebel, E.M., Pilione, MR, Kennett, M.J., Harvill, E.T. (2007) Use of a Genetically Defined Double Mutant strain of B. bronchiseptica Lacking Adenylate Cyclase and Type III Secretion as a Live Vaccine. Infection and Immunity. 75 (7):3665-3672. PDF

Gopinathan, L., Kirimanjeswara, G.S., Wolfe, D.N., Kelly, M.L., Harvill, E.T., (2007) Different mechanisms of vaccine-induced and infection-induced immunity to Bordetella bronchiseptica. Microbes and Infection. 9(4):442-8. PDF

Wolfe, D.N., Mann, P.B., Buboltz, A.M., and Harvill, E.T. (2007) Delayed role of tumor necrosis factor-α in overcoming the effects of pertussis toxin. Journal of Infectious Diseases. 196(8):1228-36. PDF

Thakar, J., Pilione, M., Kirimanjeswara, G., Harvill, E. T., Albert, R. (2007) Modeling systems-level regulation of host immune responses. PLoS Computational Biology. 8;3(6):e109. PDF

Wolfe, D.N., Kirimanjeswara, G.S., Goebel, E.M. and Harvill, E.T. (2007) Comparative Role of Immunoglobulin A in Protective Immunity Against the bordetellae. Infection and Immunity. 75(9):4416-22 PDF

MacArthur I, Mann PB, Harvill ET, Preston A (2007) Bordetella evolution: lipid A and Toll-like receptor 4. J Endotoxin Res. 2007;13(4):243-7. PDF

Wolfe DN, Goebel EM, Bjornstad ON, Restif O, Harvill ET. (2007) The O antigen enables Bordetella parapertussis to avoid Bordetella pertussis-induced immunity. Infection and Immunity. 2007 Oct;75(10):4972-9. PDF

Mann, P.B., Preston, A., Kennett, M.J., and Harvill, E.T. (2005), Comparative TLR4 Mediated Innate Host Defense to Bordetella Infection. Infection and Immunity. 73(12):8144-52. PDF

Pilione, M.R., Harvill, E.T. (2006) The Bordetella type three secretion system inhibits IFNg production that is required for efficient antibody-mediated bacterial clearance –Infection and Immunity. 74(2):1043-9. PDF

Jaewook Joo, Michelle Gunny, Marisa Cases , Peter Hudson , Réka Albert , Eric Harvill, Bacteriophage-mediated competition in Bordetella bacteria. Proc. Roy. Soc. B. (2006) Synopsis PDF

Pilione, M.R., Harvill, E.T. (2006) The Bordetella type three secretion system inhibits IFNg production that is required for efficient antibody-mediated bacterial clearance –Infection and Immunity. 74(2):1043-9. PDF

Pilione, M., Luis M. Agosto, Mary J. Kennett and Eric T. Harvill CD11b is required for the resolution of inflammation induced by Bordetella bronchiseptica respiratory infection. Cell. Microbiol. (2006) Synopsis PDF

Pilione, M.R., Harvill, E.T. (2006) The Bordetella type three secretion system inhibits IFNg production that is required for efficient antibody-mediated bacterial clearance –Infection and Immunity. 74(2):1043-9.

Mann, P.B., Preston, A., Kennett, M.J., and Harvill, E.T. (2005), Comparative TLR4 Mediated Innate Host Defense to Bordetella Infection. Infection and Immunity. 73(12):8144-52.

Hughes, M.A., Green, C.S., Lowchyj, L., Lee, G., Grippe, V.K., Smith, Jr., M.F., Huang, C.L., Harvill, E.T and Merkel, T.J. (2005) MyD88-dependent signaling confers protection to Bacillus anthracis spore challenge in mice: Implications for Toll-Like Receptor Signaling. Infection and Immunity 73(11):7535-40. PDF

Wolfe, D., Kirimanjeswara, G.S., Harvill, E.T. (2005) Clearance of Bordetella parapertussis from the lower respiratory tract requires humoral and cellular immunity – Infection and Immunity 73:6508-6513. PDF

Kirimanjeswara, G.S., Agosto, L.M., Kennett, M.J., Bjornstad, O.N. and Harvill, E.T (2005) Pertussis toxin inhibits neutrophil recruitment to delay antibody-mediated clearance of Bordetella pertussis – Journal of Clinical Investigations. 115(12):3594-601. PDF

Kirimanjeswara, G.S., Mann, P.B., Pilione, M.R., Kennett, M.J. and Harvill, E.T. (2005) The complex mechanism of antibody-mediated clearance of Bordetella from the lungs requires TLR4. J. Immunol. 175(11):7504-11. PDF

Skinner, J.A., Pilione, M.R., Shen, H., Harvill, E.T. and Yuk, M.H. (2005) Bordetella type III secretion modulates dendritic cell function resulting in immunosuppression and bacterial persistence. J. Immunol. 175:4647-4652. PDF

Bjornstad, O.N., Harvill, E.T., (2005) Evolution and Emergence of Bordetella in Humans. Trends in Microbiology, 13(8):355-9. Synopsis PDF

Harvill, E.T. Lee, G., Grippe, V.K., and Merkel, T.J. (2005) Complement Depletion Renders C57BL/6 Mice Sensitive to the Bacillus anthracis Sterne Strain. Infection and Immunity, 73(7):4420-2. PDF

Elder, K.D. and Harvill, E.T. (2004). Strain-Dependent Role of BrkA during Bordetella pertussis Infection of the Murine Respiratory Tract. Infection and Immunity, 72(10):5919-24.

Mann, P.B., Elder, K.D., Kennett, M.J., and Harvill, E.T. (2004), TLR4 Dependent Early Elicited TNFa Expression is Critical for Innate Host Defense Against Bordetella bronchiseptica. Infection and Immunity. 72(11):6650-8. PDF
http://www.vetsci.psu.edu/HarvillLab/WT&TLR4BbLPSarraydata.xls
http://www.vetsci.psu.edu/HarvillLab/WT&TLR4RB50arraydata.xls

Pilione MR, Pishko EJ, Preston A, Maskell DJ, Harvill ET. (2004) pagP is required for resistance to antibody-mediated complement lysis during Bordetella bronchiseptica respiratory infection. Infection and Immunity. 72(5):2837-42.

Liu, M., Liu, Y., Doulatov, S.R., Gingery, M., Eiserling, F.A., Baker, S., Davis, P., Preston, A., Maskell, D.J., Harvill, E.T., Parkhill, J. and Miller, J.F. (2004) Genomic and genetic analysis of Bordetella bacteriophages encoding reverse transcriptase-mediated tropism-switching cassettes.
J Bacteriol. 186(5):1503-17.

Pishko, E.J., Kirimanjeswara, G.S, Gopinathan, L., Pilione, M.R., Kennett, M.J. and Harvill, E.T., (2004) Antibody-mediated Bacterial Clearance from the Lower Respiratory Tract of Mice Requires Complement Component C3. Eur J Immunol. 34(1):184-93.

Mann, P.B., Kennett, M.J., Harvill, E.T., (2004),Toll-Like Receptor 4 Is Critical to Innate Host Defense in a Murine Model of Bordetellosis. J Infect Dis. 2004 Mar 1;189(5):833-836.
Kirimanjeswara, G.S., Mann, P.B., Harvill, E.T., (2003) The Role of Antibodies in Immunity to Bordetella Infections, Infection and Immunity, 71(4):1719-1724

A. Preston*, E. Maxim, E. Toland, E.J. Pishko1, E.T. Harvill1, M. Caroff2 and Duncan J. Maskell, (2003) Bordetella bronchiseptica PagP is a Bvg-regulated lipid A palmitoyl transferase that is required for persistent colonisation of the mouse respiratory tract. Molecular Microbiology, 48(3):725-736.

Burns VC, Pishko EJ, Preston A, Maskell DJ, Harvill ET. Role of Bordetella O antigen in respiratory tract infection. Infect Immun. 2003 Jan;71(1):86-94. PMID: 12496152

Heininger U, Cotter PA, Fescemyer HW, Martinez de Tejada G, Yuk MH, Miller JF, Harvill ET. Comparative phenotypic analysis of the Bordetella parapertussis isolate chosen for genomic sequencing. Infect Immun. 2002 Jul;70(7):3777-84. PMID: 12065521

Le LQ, Kabarowski JH, Weng Z, Satterthwaite AB, Harvill ET, Jensen ER, Miller JF, Witte ON. Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome. Immunity. 2001 May;14(5):561-71. PMID: 11371358

E. T. Harvill, A. Preston, P. A. Cotter, A. G. Allen, D. J. Maskell and J. F. Miller. 2000. Multiple roles for Bordetella lipopolysaccharide molecules during respiratory tract infection. Infect. Immun. 68(12):6720-6728.

E. T. Harvill and J. F. Miller. 2000. Manipulating the host to study bacterial virulence. Curr. Opin. Microbiol. 3(1):93–96.

M. H. Yuk, E. T. Harvill, P. A. Cotter, and J. F. Miller. 2000. Modulation of host immune responses, induction of apoptosis and inhibition of NF-kappaB activation by the Bordetella type III secretion system. Mol. Microbiol. 35(5):991–1004.

E. T. Harvill, P. A. Cotter, and J. F. Miller. 1999. Pregenomic comparative analysis between Bordetella bronchiseptica RB50 and Bordetella pertussis TohamaI in murine models of respiratory tract infection. Infect. Immun. 67(11):6109–18.

E. T. Harvill, P. A. Cotter, M. H. Yuk, and J. F. Miller. 1999. Probing the function of Bordetella bronchiseptica adenylate cyclase toxin by manipulating host immunity. Infect. Immun. 67(3):1493–500.

M. H. Yuk, E. T. Harvill, and J. F. Miller. 1997. The BvgAS Virulence Control System Regulates Type III Secretion in Bordetella bronchiseptica . Mol. Microbiol. 28(5):945-959.