My primary research interest is the pathogenesis of infectious disease; most specifically, virulence factors involved in initial colonization of the host and mucosal immune responses. Current efforts are directed toward pathology, and the identification and characterization of virulence factors of Bordetella bronchiseptica , and B. pertussis. We are studying the host immune response to Bordetella infections in transgenic and immunocompromised mice in order to better understand the pathogenesis of respiratory infections and the specific immune responses that are effective in clearance of bacteria from the upper and lower respiratory tract.

In addition, my interests include laboratory animal resource management, comparative medicine, animal behavior and well being, and the preventative and clinical veterinary care of research animals.

Hollingshead HE, Morimura K, Adachi M, Kennet MJ , Billin AN, Willson TM, Gonzalez FJ, Peters JM.  PPARbeta/delta Protects Against Experimental Colitis Through a Ligand-Independent Mechanism. Dig Dis Sci. 2007 Apr 3; [Epub ahead of print]

Tompkins S.M., Lin Y., Leser G.P., Kramer K.A., Haas D.L., Howerth E.W., Xu J., Kennet M.J. , Durbin R.K., Durbin J.E., Tripp R., Lamb R.A., He B.  Recombinant parainfluenza virus 5 (PIV5) expressing the influenza A virus hemagglutinin provides immunity in mice to influenza A virus challenge. Virology. 2007 May 25;362(1):139-50. Epub 2007 Jan 23.

Marin, H.E. Peraza, M.A., Billin, A.N., Willson, T.M., Ward, J.M., Kennett, M.J., Gonzalez, F.J. and Peters, J.M..  (2006).  Ligand activation of peroxisome proliferator-activated receptor beta inhibits colon carcinogenesis.  Cancer Res .  Apr 15; 66(8):4394-4401.

Pilione M.R., Agosto L.M. , Kennet M.J. , Harvill E.T. .  (2006).  CD11b is required for the resolution of inflammation induced by Bordetella bronchiseptica respiratory infection.  Cell Microbiol.   May; 8(5):758-68. 

Kirimanjeswara GS, Mann PB, Pilione M, Kennet MJ, Harvill ET. (2005)The Complex Mechanism of Antibody-Mediated Clearance of Bordetella from the Lungs Requires TLR4. J Immunol. Dec 1;175(11):7504-11.

Kirimanjeswara GS, Agosto LM, Kennet MJ, Bjornstad ON , Harvill ET. (2005) Pertussis toxin inhibits neutrophil recruitment to delay antibody-mediated clearance of Bordetella pertussis . J Clin Invest. Nov 17; J Clin Invest.  Dec;115(12):3594-601. Epub 2005 Nov 17.

Hays T, Rusyn I, Burns AM, Kennet MJ, Ward JM, Gonzalez FJ, Peters JM. (2005) Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis. Carcinogenesis. Jan;26(1):219-27.

Foster St. Claire, M. B., M. J. Kennett, M. L. Thomas, and J.W. Daly. (2005) The Husbandry and Care of Dendrobatid Frogs. Contemp Topic Lab Anim Sci. 44 (6) 8-14.

Mann PB, Elder KD, Kennet MJ, Harvill ET. (2004)Toll-like receptor 4-dependent early elicited tumor necrosis factor alpha expression is critical for innate host defense against Bordetella bronchiseptica . Infect Immun. Nov;72(11):6650-8.

Kim DJ, Akiyama TE, Harman FS, Burns AM, Shan W, Ward JM, Kennet MJ, Gonzalez FJ, Peters JM . (2004) Peroxisome proliferator-activated receptor beta (delta)-dependent regulation of ubiquitin C expression contributes to attenuation of skin carcinogenesis. J Biol Chem. May 28;279(22):23719-27. Epub 2004 Mar 19.

Mann, P.A., Kennett, M. J. and E. T. Harvill. (2004) TLR4 is Critical to Innate and Vaccine-Mediated Protection in a Murine Model of Bordetellosis. J Infect Dis. Mar 1;189(5):833-6. Epub 2004 Feb 17.

Pishko E.J., Kirimanjeswara G.S., Pilione M.R., Gopinathan L., Kennet M.J., Harvill E.T. (2004) Antibody-mediated bacterial clearance from the lower respiratory tract of mice requires complement component C3. Eur J Immunol. Jan; 34(1):184-93.

St. Claire, M.B., C.L. Besch-Williford, and M.J. Kennett. (2004) Vitamin A Toxicity and Vitamin E Deficiency in a Rabbit Colony. Contemp Top Lab Anim Sci. 43(4)

Carter, D.B., M.J. Kennett, and C. L. Franklin. (2002). The Use of Perphenazine to Control Cannibalism in DBA/1 Mice. Comp Med. Oct;52(5):452-5.

Kennett, M. J. and R. R. Hook. (2002) Characterization and Partial Purification of a Tritrichomonas foetus Cytotoxin. Exp Parasitol. Sep;102(1):1-8.

Kennett, M. J., R. R. Hook Jr., C. L. Franklin, and L. K. Riley. (1999). Acanthamoeba castellanii : Characterization of an adhesin molecule. Exp Parasitol. 92(3): 161-9.

Kendall, L. V., M. J. Kennett, R. E. Fish. (1998). The Short Term Care of White Tailed Deer ( Odocoileus virginianus ) Fawns in a Conventional Laboratory Animal Facility. Contemp Top Lab Anim Sci. 37(5) 96 –100.